Ash and the gang first met Clair when the discovered a Dratini and Gyarados in a river near Blackthron City, the two belonging to Clair. Team Rocket eventually tries to kidnap the Dratini, and Clair chased after them. After managing to escape from Team Rocket, an electric shock began to head towards Dratini, to which Clair jumped in the way to protect her Pokémon. Due to Clair's devotion towards her Pokémon, Dratini evolved into a Dragonair and managed to stop Team Rocket.

After the issue with Team Rocket was over, Clair accepted Ash's challenged for the Rising Badge. During the battle, Team Rocket stole the Dragon Fang. In an attempt to retrieve it again, Ash, Clair and Team Rocket all ended up in the Dragon Holy Land, where Team Rocket tricked a Dragonite into helping them. Luckily, Liza and Ash's Charizard arrived to help save the day. Ash's Charizard then helped him earn him his final Johto League Badge by defeating Clair's Dragonair.

Clair reappeared later in the Anime Series, when she bumped into Ash and the gang in Cave Island, as she was in the middle of searching for a shiny Druddigon. She appeared one last time in a later episode called A Pokémon of a Different Color! (episode BW136), when she bumped into Iris while she was in the Johto region.

Debonaire Dragonair expressing her disappoint at the lack of capable Trainers wishing to battle her. So she heads off to Dragon's Den to train with the Pokémon inside, only to find the Legendary Pokémon Suicune, who then challenges Clair to battle and manages to defeat her. After it leaves, it is revealed that Suicune appears to Trainers it deems worthy and challenges them to battle. Clair deduces that Suicune must be battling the Gym Leaders to see which one is worthy enough to be its Trainer.

At the Indigo Plateau, Clair arrives with her fellow Johto Gym Leaders to take place exhibition tournament for the Pokémon League against the Kanto Gym Leaders. She is set to face against Blaine, in the seventh round, but the match is postponed due to Blaine not feeling well. When the Masked Man attacks the Pokémon League, Clair and the other Gym Leaders combat his army of mind-controlled Team Rocket Grunts. The fight takes them to the Magnet Train, which is used as a diversion to get the Gym Leaders away from the stadium.